Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids. Cvetkovic C, Patel R, Shetty A, Hogan MK, Anderson M, Basu N, Aghlara-Fotovat S, Ramesh S, Sardar D, Veiseh O, Ward ME, Deneen B, Horner PJ, Krencik R. J Cell Biol. 2022 Feb 9;221(4):e202107135.

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage. Sadaf H, Desai VR, Misra V, Golanov E, Hegde ML, Villapol S, Karmonik C, Regnier-Golanov A, Sayenko D, Horner PJ, Krencik R, Weng YL, Vahidy FS, Britz GW. Annals of Clinical and Translational Neurology. 2021 Nov;8(11):2211-2221.

Humanized Biomimetic Nanovesicles for Neuron Targeting. Zinger A, Cvetkovic C, Sushnitha M, Naoi T, Baudo G, Anderson M, Shetty A, Basu N, Covello J, Tasciotti E, Amit M, Xie T, Taraballi F, Krencik R. Advanced Science. 2021 Aug 11.

Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies. Aghlara-Fotovat S, Nash A, Kim B, Krencik R, Veiseh O. Drug Delivery and Translational Research. 2021 Jun 26.

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T. Neurotherapeutics. 2021 Jun 23.

Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds. Sardar D, Lozzi B, Woo J, Huang TW, Cvetkovic C, Creighton CJ, Krencik R, Deneen B. International Journal of Molecular Sciences. 2021 Apr 12;22(8):3975.

Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes. Jones, JR, Kong, L, Hanna, MG, Hoffman, B, Krencik, R, Bradley, R, Hagemann, T, Choi, J, Doers, M, Dubovis, M, Sherafat, MA, Bhattacharyya, A, Kendziorski, C, Audhya, A, Messing, A & Zhang, SC 2018, Cell Reports, vol. 25, no. 4, pp. 947-958.e4.

Synaptic microcircuit modeling with 3D cocultures of astrocytes and neurons from human pluripotent stem cells. Cvetkovic, C, Basu, N & Krencik, R 2018, Journal of visualized experiments: JoVE, vol. 2018, no. 138, e58034.

Concepts toward directing human astroplasticity to promote neuroregeneration. Patel, R, Muir, M, Cvetkovic, C & Krencik, R 2018, Developmental Dynamics.

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. Krejciova, Z, Alibhai, J, Zhao, C, Krencik, R, Rzechorzek, NM, Ullian, EM, Manson, J, Ironside, JW, Head, MW & Chandran, S 2017, The Journal of Experimental Medicine, vol. 214, no. 12, pp. 3481-3495.

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Krencik, R, Seo, K, van Asperen, JV, Basu, N, Cvetkovic, C, Barlas, S, Chen, R, Ludwig, C, Wang, C, Ward, ME, Gan, L, Horner, PJ, Rowitch, DH & Ullian, EM 2017, Stem Cell Reports, vol. 9, no. 6, pp. 1745-1753.

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. Yeh, E, Dao, DQ, Wu, ZY, Kandalam, SM, Camacho, FM, Tom, C, Zhang, W, Krencik, R, Rauen, KA, Ullian, EM & Weiss, LA 2018, Molecular Psychiatry, vol. 23, no. 8, pp. 1687-1698.

Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Retallack, H, Di Lullo, E, Arias, C, Knopp, KA, Laurie, MT, Sandoval-Espinosa, C, Mancia Leon, WR, Krencik, R, Ullian, EM, Spatazza, J, Pollen, AA, Mandel-Brehm, C, Nowakowski, TJ, Kriegstein, AR & DeRisi, JL 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 50, pp. 14408-14413.

Human astrocytes are distinct contributors to the complexity of synaptic function. Krencik, R, van Asperen, JV & Ullian, EM 2016, Brain Research Bulletin.

Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells. Hu, Y, Qu, Z-Y, Cao, S-Y, Li, Q, Ma, L, Krencik, R, Xu, M & Liu, Y 2016, Journal of Neuroscience Methods, vol. 266, pp. 42-9.

Targeting brain’s star-shaped cells may yield autism drugs. Krencik, R & Ullian EM, 2016,

Efficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition. Yuan F, Fang K-H, Cao S-Y, Qu Z-Y, Li Q, Krencik R, Xu M, Bhattacharyya A, Su Y-W, Zhu D-Y & Liu Y 2015, Scientific Reports, vol. 5, pp. 18550.

Xing L, Li X, Snider WD. Science. 2015 May 8;348(6235):636-7.

Dysregulation of astrocyte extracellular signaling in Costello syndrome. Krencik, R, Hokanson, KC, Narayan, AR, Dvornik, J, Rooney, GE, Rauen, KA, Weiss, LA, Rowitch, DH & Ullian, EM 2015, Science Translational Medicine, vol. 7, no. 286, pp. 286ra66.

Acknowledgment:  Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Nature. 2014 May 8;509(7499):189-94.

Acknowledgment: Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons. Williams EC, Zhong X, Mohamed A, Li R, Liu Y, Dong Q, Ananiev GE, Mok JC, Lin BR, Lu J, Chiao C, Cherney R, Li H, Zhang SC, Chang Q. Hum Molecular Genetics. 2014 Jun 1;23(11):2968-80.

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. Nature Biotechnology. 2013 May;31(5):440-7.

A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies. Krencik R & Ullian EM. Frontiers in Cellular Neuroscience. 2013 Mar 14;7:25.

Astrocytes and disease: a neurodevelopmental perspective. Molofsky AV, Krencik R, Ullian EM, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Genes and Development. 2012 May 1;26(9):891-907.

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells. Krencik R & Zhang SC. Nature Protocols. 2011 Oct 13;6(11):1710-7.

Specification of transplantable astroglial subtypes from human pluripotent stem cells. Krencik R, Weick JP, Liu Y, Zhang ZJ, Zhang SC. Nature Biotechnology. 2011 May 22;29(6):528-34.

The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin. Bao X, Cai W, Deng H, Zhang W, Krencik R, Girton J, Johansen J, Johansen KM. Journal of Biological Chemistry. 2008 Nov 21;283(47):32741-50. doi: 10.1074/jbc.M806227200.

Stem cell neural differentiation: A model for chemical biology. Krencik R & Zhang SC. Current Opinion in Chemical Biology. 2006 Dec;10(6):592-7.

The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. Bao X, Zhang W, Krencik R, Deng H, Wang Y, Girton J, Johansen J, Johansen KM. J Cell Sci. 2005 Nov 1;118(Pt 21):5079-87.

Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K, Kang UJ. Journal of Biological Chemistry. 2004 Dec 10;279(50):51783-92.

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