Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes. Jones, JR, Kong, L, Hanna, MG, Hoffman, B, Krencik, R, Bradley, R, Hagemann, T, Choi, J, Doers, M, Dubovis, M, Sherafat, MA, Bhattacharyya, A, Kendziorski, C, Audhya, A, Messing, A & Zhang, SC 2018, Cell Reports, vol. 25, no. 4, pp. 947-958.e4. https://doi.org/10.1016/j.celrep.2018.09.083

Synaptic microcircuit modeling with 3D cocultures of astrocytes and neurons from human pluripotent stem cells. Cvetkovic, C, Basu, N & Krencik, R 2018, Journal of visualized experiments: JoVE, vol. 2018, no. 138, e58034. https://doi.org/10.3791/58034

Concepts toward directing human astroplasticity to promote neuroregeneration. Patel, R, Muir, M, Cvetkovic, C & Krencik, R 2018, Developmental Dynamics. https://doi.org/10.1002/dvdy.24655

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. Krejciova, Z, Alibhai, J, Zhao, C, Krencik, R, Rzechorzek, NM, Ullian, EM, Manson, J, Ironside, JW, Head, MW & Chandran, S 2017, The Journal of Experimental Medicine, vol. 214, no. 12, pp. 3481-3495. https://doi.org/10.1084/jem.20161547

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Krencik, R, Seo, K, van Asperen, JV, Basu, N, Cvetkovic, C, Barlas, S, Chen, R, Ludwig, C, Wang, C, Ward, ME, Gan, L, Horner, PJ, Rowitch, DH & Ullian, EM 2017, Stem Cell Reports, vol. 9, no. 6, pp. 1745-1753. https://doi.org/10.1016/j.stemcr.2017.10.026

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. Yeh, E, Dao, DQ, Wu, ZY, Kandalam, SM, Camacho, FM, Tom, C, Zhang, W, Krencik, R, Rauen, KA, Ullian, EM & Weiss, LA 2018, Molecular Psychiatry, vol. 23, no. 8, pp. 1687-1698. https://doi.org/10.1038/mp.2017.238

Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Retallack, H, Di Lullo, E, Arias, C, Knopp, KA, Laurie, MT, Sandoval-Espinosa, C, Mancia Leon, WR, Krencik, R, Ullian, EM, Spatazza, J, Pollen, AA, Mandel-Brehm, C, Nowakowski, TJ, Kriegstein, AR & DeRisi, JL 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 50, pp. 14408-14413. https://doi.org/10.1073/pnas.1618029113

Human astrocytes are distinct contributors to the complexity of synaptic function. Krencik, R, van Asperen, JV & Ullian, EM 2016, Brain Research Bulletin. https://doi.org/10.1016/j.brainresbull.2016.08.012

Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells. Hu, Y, Qu, Z-Y, Cao, S-Y, Li, Q, Ma, L, Krencik, R, Xu, M & Liu, Y 2016, Journal of Neuroscience Methods, vol. 266, pp. 42-9. https://doi.org/10.1016/j.jneumeth.2016.03.017

Targeting brain’s star-shaped cells may yield autism drugs. Krencik, R & Ullian EM, 2016, https://www.spectrumnews.org/opinion/viewpoint/targeting-brains-star-shaped-cells-may-yield-autism-drugs/

Efficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition. Yuan F, Fang K-H, Cao S-Y, Qu Z-Y, Li Q, Krencik R, Xu M, Bhattacharyya A, Su Y-W, Zhu D-Y & Liu Y 2015, Scientific Reports, vol. 5, pp. 18550. https://doi.org/10.1038/srep18550

Xing L, Li X, Snider WD. Science. 2015 May 8;348(6235):636-7. https://doi.org/10.1126/science.aab3738

Dysregulation of astrocyte extracellular signaling in Costello syndrome. Krencik, R, Hokanson, KC, Narayan, AR, Dvornik, J, Rooney, GE, Rauen, KA, Weiss, LA, Rowitch, DH & Ullian, EM 2015, Science Translational Medicine, vol. 7, no. 286, pp. 286ra66. https://doi.org/10.1126/scitranslmed.aaa5645

Acknowledgment:  Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Nature. 2014 May 8;509(7499):189-94. https://doi.org/10.1038/nature13161

Acknowledgment: Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons. Williams EC, Zhong X, Mohamed A, Li R, Liu Y, Dong Q, Ananiev GE, Mok JC, Lin BR, Lu J, Chiao C, Cherney R, Li H, Zhang SC, Chang Q. Hum Molecular Genetics. 2014 Jun 1;23(11):2968-80. https://doi.org/10.1093/hmg/ddu008

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. Nature Biotechnology. 2013 May;31(5):440-7. https://doi.org/10.1038/nbt.2565

A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies. Krencik R & Ullian EM. Frontiers in Cellular Neuroscience. 2013 Mar 14;7:25. https://doi.org/10.3389/fncel.2013.00025

Astrocytes and disease: a neurodevelopmental perspective. Molofsky AV, Krencik R, Ullian EM, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Genes and Development. 2012 May 1;26(9):891-907. https://doi.org/10.1101/gad.188326.112

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells. Krencik R & Zhang SC. Nature Protocols. 2011 Oct 13;6(11):1710-7. https://doi.org/10.1038/nprot.2011.405

Specification of transplantable astroglial subtypes from human pluripotent stem cells. Krencik R, Weick JP, Liu Y, Zhang ZJ, Zhang SC. Nature Biotechnology. 2011 May 22;29(6):528-34. https://doi.org/10.1038/nbt.1877

The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin. Bao X, Cai W, Deng H, Zhang W, Krencik R, Girton J, Johansen J, Johansen KM. Journal of Biological Chemistry. 2008 Nov 21;283(47):32741-50. doi: 10.1074/jbc.M806227200.

Stem cell neural differentiation: A model for chemical biology. Krencik R & Zhang SC. Current Opinion in Chemical Biology. 2006 Dec;10(6):592-7.

The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. Bao X, Zhang W, Krencik R, Deng H, Wang Y, Girton J, Johansen J, Johansen KM. J Cell Sci. 2005 Nov 1;118(Pt 21):5079-87.

Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K, Kang UJ. Journal of Biological Chemistry. 2004 Dec 10;279(50):51783-92.

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