Biofabrication of Neural Organoids: An Experiential Learning Approach for Instructional Laboratories. Cvetkovic C, Lindley S, Golecki H, Krencik R. Biomedical Engineering Education. 2024 April 30;10.1007/s43683-024-00145-7 https://link.springer.com/article/10.1007/s43683-024-00145-7
Asteroid impact: the potential of astrocytes to modulate human neural networks within organoids. Lavekar SS, Patel MD, Montalvo-Parra MD, Krencik R. Frontiers in Neuroscience. 2023 Nov 22;17:1305921. https://doi: 10.3389/fnins.2023.1305921
Machine learning dissection of human accelerated regions in primate neurodevelopment. Whalen S, Inoue F, Ryu H, Fair T, Markenscoff-Papadimitriou E, Keough K, Kircher M, Martin B, Alvarado B, Elor O, Laboy Cintron D, Williams A, Hassan Samee MA, Thomas S, Krencik R, Ullian EM, Kriegstein A, Rubenstein JL, Shendure J, Pollen AA, Ahituv N, Pollard KS. Neuron. 2023 Jan 5:S0896-6273(22)01123-0. https://doi.org/10.1016/j.neuron.2022.12.026
Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids. Cvetkovic C, Patel R, Shetty A, Hogan MK, Anderson M, Basu N, Aghlara-Fotovat S, Ramesh S, Sardar D, Veiseh O, Ward ME, Deneen B, Horner PJ, Krencik R. J Cell Biol. 2022 Feb 9;221(4):e202107135. https://doi.org/10.1083/jcb.202107135
A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage. Sadaf H, Desai VR, Misra V, Golanov E, Hegde ML, Villapol S, Karmonik C, Regnier-Golanov A, Sayenko D, Horner PJ, Krencik R, Weng YL, Vahidy FS, Britz GW. Annals of Clinical and Translational Neurology. 2021 Nov;8(11):2211-2221. https://doi.org/10.1002/acn3.51443
Humanized Biomimetic Nanovesicles for Neuron Targeting. Zinger A, Cvetkovic C, Sushnitha M, Naoi T, Baudo G, Anderson M, Shetty A, Basu N, Covello J, Tasciotti E, Amit M, Xie T, Taraballi F, Krencik R. Advanced Science. 2021 Aug 11. https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101437
Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies. Aghlara-Fotovat S, Nash A, Kim B, Krencik R, Veiseh O. Drug Delivery and Translational Research. 2021 Jun 26. https://doi.org/10.1007/s13346-021-01018-0
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T. Neurotherapeutics. 2021 Jun 23. https://doi.org/10.1007/s13311-021-01075-w
Mapping Astrocyte Transcriptional Signatures in Response to Neuroactive Compounds. Sardar D, Lozzi B, Woo J, Huang TW, Cvetkovic C, Creighton CJ, Krencik R, Deneen B. International Journal of Molecular Sciences. 2021 Apr 12;22(8):3975. https://doi.org/10.3390/ijms22083975
Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes. Jones, JR, Kong, L, Hanna, MG, Hoffman, B, Krencik, R, Bradley, R, Hagemann, T, Choi, J, Doers, M, Dubovis, M, Sherafat, MA, Bhattacharyya, A, Kendziorski, C, Audhya, A, Messing, A & Zhang, SC 2018, Cell Reports, vol. 25, no. 4, pp. 947-958.e4. https://doi.org/10.1016/j.celrep.2018.09.083
Synaptic microcircuit modeling with 3D cocultures of astrocytes and neurons from human pluripotent stem cells. Cvetkovic, C, Basu, N & Krencik, R 2018, Journal of visualized experiments: JoVE, vol. 2018, no. 138, e58034. https://doi.org/10.3791/58034
Concepts toward directing human astroplasticity to promote neuroregeneration. Patel R, Muir M, Cvetkovic C & Krencik R 2018, Developmental Dynamics. https://doi.org/10.1002/dvdy.24655
Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside JW, Head MW & Chandran S 2017, The Journal of Experimental Medicine, vol. 214, no. 12, pp. 3481-3495. https://doi.org/10.1084/jem.20161547
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH & Ullian EM 2017, Stem Cell Reports, vol. 9, no. 6, pp. 1745-1753. https://doi.org/10.1016/j.stemcr.2017.10.026
Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. Yeh E, Dao DQ, Wu ZY, Kandalam SM, Camacho FM, Tom C, Zhang W, Krencik R, Rauen KA, Ullian EM & Weiss LA 2018, Molecular Psychiatry, vol. 23, no. 8, pp. 1687-1698. https://doi.org/10.1038/mp.2017.238
Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR & DeRisi JL 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 50, pp. 14408-14413. https://doi.org/10.1073/pnas.1618029113
Human astrocytes are distinct contributors to the complexity of synaptic function. Krencik R, van Asperen JV & Ullian EM 2016, Brain Research Bulletin. https://doi.org/10.1016/j.brainresbull.2016.08.012
Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells. Hu Y, Qu Z-Y, Cao S-Y, Li Q, Ma L, Krencik R, Xu M & Liu Y 2016, Journal of Neuroscience Methods, vol. 266, pp. 42-9. https://doi.org/10.1016/j.jneumeth.2016.03.017
Targeting brain’s star-shaped cells may yield autism drugs. Krencik R & Ullian EM, 2016, https://www.spectrumnews.org/opinion/viewpoint/targeting-brains-star-shaped-cells-may-yield-autism-drugs/
Efficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition. Yuan F, Fang K-H, Cao S-Y, Qu Z-Y, Li Q, Krencik R, Xu M, Bhattacharyya A, Su Y-W, Zhu D-Y & Liu Y 2015, Scientific Reports, vol. 5, pp. 18550. https://doi.org/10.1038/srep18550
“RASopathic” astrocytes constrain neural plasticity. Xing L, Li X, Snider WD. Science. 2015 May 8;348(6235):636-7. https://doi.org/10.1126/science.aab3738
Dysregulation of astrocyte extracellular signaling in Costello syndrome. Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH & Ullian EM 2015, Science Translational Medicine, vol. 7, no. 286, pp. 286ra66. https://doi.org/10.1126/scitranslmed.aaa5645
Acknowledgment: Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Nature. 2014 May 8;509(7499):189-94. https://doi.org/10.1038/nature13161
Acknowledgment: Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons. Williams EC, Zhong X, Mohamed A, Li R, Liu Y, Dong Q, Ananiev GE, Mok JC, Lin BR, Lu J, Chiao C, Cherney R, Li H, Zhang SC, Chang Q. Hum Molecular Genetics. 2014 Jun 1;23(11):2968-80. https://doi.org/10.1093/hmg/ddu008
Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. Nature Biotechnology. 2013 May;31(5):440-7. https://doi.org/10.1038/nbt.2565
A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies. Krencik R & Ullian EM. Frontiers in Cellular Neuroscience. 2013 Mar 14;7:25. https://doi.org/10.3389/fncel.2013.00025
Astrocytes and disease: a neurodevelopmental perspective. Molofsky AV, Krencik R, Ullian EM, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Genes and Development. 2012 May 1;26(9):891-907. https://doi.org/10.1101/gad.188326.112
Directed differentiation of functional astroglial subtypes from human pluripotent stem cells. Krencik R & Zhang SC. Nature Protocols. 2011 Oct 13;6(11):1710-7. https://doi.org/10.1038/nprot.2011.405
Specification of transplantable astroglial subtypes from human pluripotent stem cells. Krencik R, Weick JP, Liu Y, Zhang ZJ, Zhang SC. Nature Biotechnology. 2011 May 22;29(6):528-34. https://doi.org/10.1038/nbt.1877
The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin. Bao X, Cai W, Deng H, Zhang W, Krencik R, Girton J, Johansen J, Johansen KM. Journal of Biological Chemistry. 2008 Nov 21;283(47):32741-50. doi: 10.1074/jbc.M806227200.
Stem cell neural differentiation: A model for chemical biology. Krencik R & Zhang SC. Current Opinion in Chemical Biology. 2006 Dec;10(6):592-7.
The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. Bao X, Zhang W, Krencik R, Deng H, Wang Y, Girton J, Johansen J, Johansen KM. J Cell Sci. 2005 Nov 1;118(Pt 21):5079-87.
Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K, Kang UJ. Journal of Biological Chemistry. 2004 Dec 10;279(50):51783-92.